TCM China:

Record of Herbal Treatment Of Jose from Portugal Improvement Of ALS


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Records of Hospitalization

Name: Jose                                   Sex: Male

Age: 57                                            Profession:  Office Clerk

Nationality: Portugal                     Marital status: Married

Onset Season: Summer                  Date of Admission: Sept. 13th 2007  

Complainer: The patient himself   Reliability: Reliable

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Major complaint: The patient has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for one year.

Present illness: In June 2004, the patient began to feel weakness of the lower limbs without any obvious causes. At that time, the patient paid no attention to it, and did no treatment about it. Therefore, the disease was developing progressively. Three months later, the patient began to suffer from muscular atrophy, but he still took no treatment. In Aug. 2005, the patient went to a local hospital for a diagnosis. After the EMG examination, he was diagnosed with amyotrophic lateral sclerosis (ALS). The patient was told that there may be some unpleasantness to happen in the future. In Oct. 2005, the patient began to take Rilutek up to now. From Mar. 2006 to Mar. 2007, the patient received the treatment of acupuncture and massage for twice a week in a local hospital, but he got no obvious improvement. In the second half of 2006, the patient¡¯s condition aggravated and even was not able to walk. Therefore, his movement had to be supported by a wheelchair. To seek for a further comprehensive treatment, he hospitalized in our hospital on Sept. 13th 2007. Since he got the disease, his spirit was poor, but his appetite was normal. His sleep was sound. His urination was normal, and his bowel movement was hard.

Disease history: No history of typhoid, tuberculosis, hepatitis, malaria or other infectious disease. No allergic history of medicine or food. No history of blood transfusion. No history of preventive vaccination provided. In 1975, he had a trauma due to a car accident which resulted in his left tibia fracture, and then he received the treatment of Compression Plate Fixation. In 1997, he received the resection on his appendicitis in a local hospital, and now he recovered completely.

 

Personal history: he was born in Portugal. No contact history of schistosomiasis. No addiction to smoking, alcohol or special food. He was mild-tempered and open-minded.

Marital history: he got married at 27. Now he has three daughters. His wife and children have been healthy all the time.

Family history: His parents were both healthy. No family history of special disease.

Physical examination:

T 36.3¡æ£¬P: 74bpm, R: 20bpm, BP: 140/80 mmHg

He was mid-nourished and normally developed. His mind was clear. He had an expression of chronic illness and languidness. He was in a positive position and cooperative in examination. His skin was moist. No jaundice in the sclera. No superficial lymph-node enlargement. Bilateral pupils were round and equal in size and sensitive to light. No abnormity of skull and five organs. No enlargement of his tonsils. With soft neck and trachea placed in the middle. No enlargement of the thyroid gland. No turgor jugular vein. No thoracic deformity. Sound of breath was bilaterally normal on auscultation. No respiratory rales or pleural friction rubs. Heart border was normal. Heart beat 74 times/min. Cardiac rhythm was regular. No pathological murmurs on auscultation. Abdomen touched flat and soft without tenderness or rebound tenderness. Liver and spleen were not palpable. No percussion pain in renal region. Bowel sound was normal. No spinal and pelvic deformity or tenderness. His upper limbs were in free movement, but his lower limbs were weak, accompanied with difficulty in movement and disability of walking. Besides, both lower limbs¡¯ movement of flexion and extension completely paralyzed. Both gastrocnemius and soleus of his lower limbs were serious atrophic, and muscles of his feet were also obviously atrophic. The muscles of all over his body beat uncontrollably and frequently. His lower limbs were Grade ¢ó with lower muscle hyperthyroidism. The examinations to the anus and pudendum were both normal. His physiological reflex has not been elicited. His tongue was red with slightly yellow tongue coating, and there were cracks in the middle with teeth-marks at the edge of the tongue. His pulse was fine and weak.

Diagnostic examination: Not provided.

First diagnosis: 

TCM diagnosis: Wei-syndrome (flaccidity syndrome)

Symptom diagnosis: liver-kidneys yin vacuity.

WM diagnosis: Amyotrophic Lateral Sclerosis (ALS)

 

First Medical Record

                                             July 18th 2007 

Jose, a 57-year-old male, has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for one year. He was picked up by our staff in Zhijiang Airport and arrived in Huaihua Red Cross Hospital for further treatment at 19: 00p.m on Sept. 13th 2007.

 

Essentials for diagnosis:

1. The patient has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for one year.

2. In June 2004, the patient began to feel weakness of the lower limbs without any obvious causes. At that time, the patient paid no attention to it, and did no treatment about it. Therefore, the disease was developing progressively. Three months later, the patient began to suffer from muscular atrophy, but he still took no treatment. In Aug. 2005, the patient went to a local hospital for a diagnosis. After the EMG examination, he was diagnosed with amyotrophic lateral sclerosis (ALS). The patient was told that there may be some unpleasantness to happen in the future. In Oct. 2005, the patient began to take Rilutek up to now. From Mar. 2006 to Mar. 2007, the patient received the treatment of acupuncture and massage for twice a week in a local hospital, but he got no obvious improvement. In the second half of 2006, the patient¡¯s condition aggravated and even was not able to walk. Therefore, his movement had to be supported by a wheelchair. To seek for a further comprehensive treatment, he hospitalized in our hospital on Sept. 13th 2007. Since he got the disease, his spirit was poor, but his appetite was normal. His sleep was sound. His urination was normal, and his bowel movement was hard.

3. T 36.3¡æ£¬P: 74bpm, R: 20bpm, BP: 140/80 mmHg

4. He was mid-nourished and normally developed. His mind was clear. He had an expression of chronic illness and languidness. He was in a positive position and cooperative in examination.

5. His lower limbs were weak, accompanied with difficulty in movement and disability of walking. Both gastrocnemius and soleus of his lower limbs were serious atrophic, and muscles of his feet were also obviously atrophic. Both lower limbs were completely paralyzed. Below the ankle-joints, there were apparently swelling. The muscles of all over his body beat uncontrollably and frequently. His lower limbs were Grade ¢ó with lower muscle hyperthyroidism.

6. No thoracic deformity. Chest percussion noted resonance. Sound of breath is bilaterally clear on auscultation. No sound of pleural friction.

7. Diagnostic examination: Not provided

 

Diagnostic basis

TCM: The patient has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for one year. It belongs to vacuity of liver-kidneys and blood-essence, so it could not nourish the sinews and vessels. Therefore, it gradually results in flaccidity. With the withered marrow and dry vessels, the fat on his legs became thinner, and so he kept a decadent spirit. The kidneys are in charge of bone-marrow. Due to lack of the essence, his waist-ridge was wilting with difficulty in movement. His tongue was red with slightly yellow tongue coating, and there were cracks in the middle with teeth-marks at the edge of the tongue. His pulse was fine and weak. All above symptoms belong to the scope of liver-kidneys Yin vacuity.

 

Western medicine: The patient has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for one year. His lower limbs were weak, accompanied with difficulty in movement and disability of walking. He could neither raise nor sway his lower limbs, and also could not do any flexible movement. Both of his lower limbs were completely paralyzed. Both gastrocnemius and soleus of his lower limbs were serious atrophic, and muscles of his feet were also obviously atrophic. The muscles of all over his body beat uncontrollably and frequently. His lower limbs were Grade ¢ó with lower muscle hyperthyroidism. After the EMG examination in Aug. 2005, he was diagnosed with amyotrophic lateral sclerosis (ALS) in a local hospital.

 

Diagnostic differentiation

TCM: The patient¡¯s Wei-syndrome should be differentiated from Bi-syndrome. In the late period of Bi-syndrome, the patient was not able to do any movement due to the aching pain of the limb joints. With apraxic limbs for a long time, the muscles were limp and atrophic, which is similar to Wei-syndrome, but it is mainly characterized by aching pain on the limb joints. While Wei-syndrome is characterized by limp and weak, in general, there was no aching pain on the limb joints. They are not difficult to be distinguished in clinics.

WM: Wei-syndrome should be differentiated from grave myasthenia gravis, which is an acquired autoimmune disease with the transferring obstacles of nerve-muscles, and is caused by the autoimmune reaction resulting from the acetylcholine receptor (AchR) of the striated muscle. It can occur at any age and there are about 60 percent people stricken before 30 years old. Women are more often affected than men are. The most obvious characteristic of MG in clinics is rapid fatigability of the skeletal muscles affected, improved with rest or medicines that inhibits the activity of cholinesterase. They are not difficult to be distinguished in clinics.

 

First diagnosis: 

TCM diagnosis: Wei-zheng (Flaccidity syndrome)

Symptom diagnosis: liver-kidneys yin vacuity.

WM diagnosis: Amyotrophic Lateral Sclerosis (ALS)

 

Plan for treatment strategy and nursing

1. On routine care of traditional Chinese internal medicine

2. On grade II care

3. Under care of a companion

4. High-protein diet

5. Herbal tea (to enrich yin and supplement the kidneys, to soften the liver and extinguish the wind): one dosage a day and drink twice

Prescription: Variable in Supplementing-Kidneys and Softening-Liver Decoction

Main herbs used in the herbal tea: Baishao (White Peony), Shudi (Cooked Rehmannia root), Chuanwu (Aconite main tuber), etc.

6. Acupuncture and massage: once a day

7. Have more medical examinations if necessary

 

Date: Sept. 14th 2007                               Time: 10:00 a.m.

The patient complained that he has suffered from weakness of the lower limbs along with muscular atrophy for 3 years, and has been aggravated by disability of walking for over one year. His lower limbs were weak with seriously atrophic, so he could neither stand nor walk. His lower limbs paralyzed completely, so he even could not do any flexible movement. There were swellings below the ankle joints. His strength of his arms lessened. He felt languid and weak. There were muscles beating with feeling of tightening on all over the body. He suffered from fuzzy eyes, wilt waist and distending stomach duct. He kept a normal diet with dry month dying to drink. His stool was dry and hard. His tongue was red with light yellow tongue coating. There were cracks in the middle of the tongue along with teeth marks at the edge of the tongue. His pulse was fine, rapid and weak. TCM diagnosed it as Flaccidity Syndrome because of the Liver-Stomach yin vacuity. Western medicine diagnosed it as Amyotrophic Lateral Sclerosis (ALS). The treatment strategy is to enrich yin and supplement the kidneys, to soften the liver and extinguish the wind.

Main herbs used in the herbal tea: Baishao (White Peony), Shudi (Cooked Rehmannia root), Chuanwu (Aconite main tuber), etc. three dosages in total. One dosage a day and drink twice

 

Date: Sept. 16th 2007                               Time: 9:00 a.m.

The patient¡¯s examinations of ECG, B-ultrasomotonography examination and blood were both normal. His urine examination was (+); the Urea Ammonia was 9.61. Considering there were some errors. The patient would have more examination if necessary. The patient said that his muscles beating all over the body lessened. Doctor¡¯s requirement: take four dosages herbal tea of the same prescription.

 

Date: Sept. 20th 2007                               Time: 9:00 a.m.

The muscular tremor all over the body almost disappeared. His lower limbs still could not do any movement, and he had to sit all the time. His lower limbs drooped, so the blood was difficult to flow back to the body, which resulted in swellings below the knee joints. The doctor advised him to lay his legs straight and do more exercise for his suffering parts. He would continue to take five dosages herbal tea of the same prescription.

 

Date: Sept. 25th 2007                               Time: 9:00 a.m.

The muscular tremor s all over the body improved significantly. He still suffered from abdominal distention with dry and hard stool. His ankle joints were stiff and unable to do any flexible movement. There were swellings below the ankle joints. The treatment is to enrich the liver and supplement kidneys, to quicken the blood and soften the hardness. He would continue to take five dosages herbal tea of the same prescription.

 

Date: Sept. 29th 2007                               Time: 9:00 a.m.

After the treatment of herbal tea and massage, the muscular tremor all over the body lessened day by day. It has been three days since the muscular tremor stopped. The stiff ankle joints and swellings improved obviously. He would continue to take herbal tea of the same prescription.

 

Date: Oct. 5th 2007                               Time: 9:00 a.m.

Both stiff ankle joints improved apparently and his toe-joints could do some slightly flexible movement. There were contracted movements among the muscles of his legs. The patient was glad to receive such great improvement, so he kept a pleasant mood. Doctor¡¯s requirement: take herbal tea of the same prescription.

 

Date: Oct. 10th 2007                               Time: 9:00 a.m.

In recent days, the patient has suffered from vomiting, poor food intake and watery stool twice a day. No stomachache. The treatment strategy is to warm the center and dissipate cold, to fortify the spleen and transform food. Doctor¡¯s requirement: take three dosages herbal tea as following: Baishu (Ovate Atratylodes root), Fulin (Poria), Dangshen (Codonopsis root), etc.

 

Date: Oct. 13th 2007                               Time: 9:00 a.m.

The patient said that his food intake was normal without any vomiting. He still suffered from abdominal distention with once dilute stool a day. Doctor¡¯s requirement: take herbal tea of the former prescription without Lycium. In recent days, the patient felt that there were muscular contracted movements among his legs and calves. He was told he was recovering in a good condition.

 

Date: Oct. 18th 2007                               Time: 10:00 a.m.

The patient complained about his uncomfortable throat. In the examination, there were swellings and congestion in the throat. He was considered to have caught a cold. The doctor added 6g Sichuan Coptis root, etc. to his herbal tea. The patient was with the symptoms of dry stool and abdominal distention. There were muscular contracted movements among his legs and calves. His left knee joints can do flexible movement, and the symptoms of swellings and livor below his ankle joints lessened, which showed that his condition was improving. There was stiffness on his ankle joints, especially serious on his left one. The patient told the doctor that he had had the history of trauma 30 years before.  

 

Date: Oct. 20th 2007                               Time: 10:00 a.m.

The patient¡¯s angina due to a cold has almost recovered. He was in poor spirit with abdominal distention and dry stool. There were symptoms of swelling below the ankle joints of his lower limbs, so the doctor advised him to eat more fruit and vegetables, and he could not only take high-protein food. The main herbs in the prescription as following: Baishu (Ovate Atratylodes root), Huangqi (Astragalus root), Dangshen (Codonopsis root), etc.   

 

Date: Oct. 23rd 2007                               Time: 10:00 a.m.

In recent days, the patient has caught a cold along with dieting outside, so he was considered that his diarrhea resulted from gastrointestinal disorder. He suffered from watery stool for twice a day, accompanied with abdominal distention, poor food intake and weakness. He was prescribed 1000ml energy mixture with potassium chloride. He orally took self-prepared medicine for his diarrhea. The TCM treatment strategy is to boost qi and fortify the spleen. The main herbs in the three dosages herbal tea as following: Baishen (White Ginseng), Huangqi (Astragalus root), Caihu (Bupelurum root), etc.

 

Date: Oct. 24th 2007                               Time: 9:00 a.m.

The patient said that his spirit got better. No abdominal distention or diarrhea. The doctor advised him that he¡¯d rather go on a light diet than a greasy or high-protein diet. He should avoid the spicy or cold food.   

 

Date: Oct. 26th 2007                               Time: 9:00 a.m.

The patient¡¯s condition was normal. He did not feel any other special discomfort. His diet increased. He was with slight abdominal distention. No diarrhea. He kept a normal spirit. The main herbs in another three dosages herbal tea: Baishen (White Ginseng), Huangqi (Astragalus root), Caihu (Bupelurum root), etc.

 

Date: Oct. 29th 2007                               Time: 14:00 p.m.

In recent two days, the patient has eaten some fruits, which resulted in diarrhea, accompanied with rectal tenesmus. He suffered with poor food intake and weakness. The patient took self-prepared medicine for his diarrhea, and he was prescribed by 1000ml + gentamicin 240,000 U and energy mixture. The patient felt no special discomfort. He continued to take two dosages herbal tea of the former formulation.     

 

Date: Oct. 31st 2007                               Time: 10:00 a.m.

The patient diarrhea recovered completely. His stool was dry with blood in it. Today the invited surgeon professor Yu examined him, and found that there were several hemorrhoids among some hard and dry stool of his anal canal. There was no other abnormality. It was considered that the patient had taken too much self-prepared medicine for diarrhea. Therefore, he was prescribed by Glycerine Enema (Kaisailu) for external use. The doctor advised him to eat more fruit and take the herbal tea for further examination. The TCM treatment strategy is to fortify the spleen and supplement the kidneys. The main herbs in the three dosages herbal tea as following: Baishen (White Ginseng), Huangqi (Astragalus root), Caihu (Bupelurum root), etc.

 

Date: Nov. 3rd 2007                               Time: 9:00 a.m.

The patient¡¯s stool was constipated and dry. After the Glycerine Enema (Kaisailu) for external use twice, he had excluded a lot of stool. His diet got better significantly, and he kept a normal spirit with good mood. The patient continued to take the herbal tea to fortify the spleen and supplement the kidneys. Doctor¡¯s requirements: take four dosages herbal tea of the same formulation.

 

Date: Nov. 7th 2007                               Time: 9:00 a.m.

In recent days, the patient has had slightly muscular beatings. His other condition was normal. Doctor¡¯s requirements: take five dosages herbal tea of the following formulation: Baishen (White Ginseng), Huangqi (Astragalus root), Baishu (Ovate Atratylodes root),, etc.

 

Date: Nov. 12th 2007                               Time: 9:00 a.m.

The patient¡¯s muscular beatings disappeared. The swellings below his ankle joints of his lower limbs lessened. The contracted strength of his lower limbs¡¯ muscles increased. His bowel movement and urination were both normal. He kept a normal diet and steady mood. There was no other abnormality. The doctor added Tangkuei to another five dosages herbal tea.

 

Date: Nov. 17th 2007                               Time: 9:00 a.m.

The stiffness of his lower limbs¡¯ ankle joints lessened significantly. His skin was in purple. There was blood block due to his tiredness after travel. Another three dosages herbal tea was invariable as following: Baishen (White Ginseng), Huangqi (Astragalus root), Baishu (Ovate Atratylodes root), etc.

 

Date: Nov. 20th 2007                               Time: 9:00 a.m.

The stiffness of his lower limbs¡¯ ankle joints lessened significantly. Doctor¡¯s requirements: take four dosages herbal tea of the foremer formulation.

 

Date: Nov. 25th 2007                               Time: 9:00 a.m.

The swellings of his lower limbs¡¯ ankle joints lessened further. There were slight swelling on his feet and back. His skin was in purple and dark. He kept a normal diet and sleep. His bowel movement and urination were both normal. Doctor¡¯s requirements: take four dosages herbal tea of the same formulation. Doctor¡¯s requirements: take six dosages herbal tea of the former formulation.

 

Date: Nov. 30th 2007                               Time: 9:00 a.m.

The patient kept a steady condition. Doctor¡¯s requirements: take four dosages herbal tea of the former formulation.

 

Date: Dec. 4th 2007                               Time: 9:00 a.m.

The muscular beatings all over his body disappeared completely. The swellings on his lower limbs almost recovered. The stiffness on his ankle joints improved significantly. The blood circulation of his lower limbs improved. He kept a normal diet, sleep and digestion. The patient took 30 dosages herbal tea of the former formulation and demanded to leave hospital.
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